Welcome to the Illegitimate microRNA Predictor (ImiRP), an open source Web application designed to selectively mutate predicted miRNA target sites while ensuring that predicted target sites for other miRNAs, termed illegitimate target sites, are not created in the process. Accidental creation of illegitimate target sites upon disruption of existing miRNA target sites can complicate analysis of miRNA-target regulation. Given the small size of miRNA recognition motifs and the abundance of identified miRNAs, the likelihood of generating an illegitimate site upon mutation of an existing site is high. This becomes even more problematic when trying to mutate multiple predicted target sites simultaneously.
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